Ketamine, commonly used as a veterinary tranquilizing agent, can also produce the types of dissociative effects associated with psychedelic drugs when abused. As with most all psychedelic substances, the effects can be unpredictable and fairly dangerous under certain circumstances.

The K-hole effect takes shape once a person enters into the dissociative state caused by Ketamine. Psychedelic drugs in general interact with essential regions in the brain, many of which regulate consciousness, perception and emotions.

While Ketamine itself is not addictive, the K-hole effect can become addictive for some users. Dangers associated with the Ketamine use become most apparent once a person experiences the K-hole effect.

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Ketamine

When used for recreational purposes, Ketamine can be snorted, injected, taken in pill form and even administered rectally. According to the National Highway Traffic Safety Administration, the “high” effect produced by Ketamine closely resembles that produced by PCP and LSD, the two most popular psychedelic drugs.

Unlike pain-blocking drugs, Ketamine’s anesthetic effects essentially shuts off the brain from the body altogether. Ketamine does this by specifically targeting the glutamate cell receptors in the brain.

When working normally, glutamate secretions from these receptors promote brain cell activity and overall brain function. Ketamine’s effects interfere with glutamine secretions and thereby warp communications between the various brain regions as well as completely shutting down certain regions.

The K-Hole Effect

A K-hole results from doing too much Ketamine in one sitting.

According to the New York University-Steinhardt, the intensity of a ketamine “high” directly corresponds with the dosage amount used. The K-hole effect typically occurs when injecting (intramuscularly) doses of 60-125 milligrams or snorting anywhere from 100 to 250 milligrams depending on a person’s weight, tolerance and biochemical response to the drug’s effects.

The K-hole effect can happen as soon as 10 to 20 minutes after taking the drug. Users first experience an inability to move followed by a total disconnect from physical sensations as hallucinations start to take shape. The inability to move when on ketamine accounts for its classification as a date rape drug.

Dangerous Effects

K-hole dangers develop out of Ketamine’s effects on the mind and body. Psychological effects typically produced by Ketamine include:

• Hallucinations
• Out-of-body experiences
• Disorientation
• Sense of invincibility
• Inability to communicate with others
• Warped thought processes
• Limited awareness of surrounding environment
• Vivid dreams

Physical effects experienced include:

• Inability to perceive pain
• Slurred speech
• Loss of coordination
• Elevated blood pressure
• Catatonic state
• Abnormally fast heart rate

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Side effects often experienced may take the form of:

• Delirium
• Chest pains
• Psychosis
• Seizures
• Paranoia
• Vomiting
• Severe anxiety
• Heart palpitations
• Flashbacks

Dangers

In high enough doses, Ketamine can cause overdose. Even in cases where overdose does not occur, the K-hole effect can place users in a state of paralysis that may or may not shut down a person’s respiratory and circulatory functions. In cases where Ketamine induces vomiting, a person’s inability to move can leave him or her choking to the point of asphyxiation.

The overall “disconnect” users experience from their surroundings can easily lead to injury or fatality. As with most psychedelic drugs, users are more likely to become psychologically addicted to Ketamine’s effects rather than physically addicted.

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